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Generic Name: chloroquine phosphate, dosage Form: Tablets, USP, show On This Page, view All. Show On This Page, for flagyl 500 mg sanofi Malaria and Extraintestinal Amebiasis, aralen Description. Aralen, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Aralen is an antimalarial and amebicidal drug. Chemically, it is phosphate (1:2) and has the following structural formula: Each tablet contains 500 mg of flagyl 500 mg sanofi chloroquine phosphate USP, equivalent to 300 mg chloroquine base. Inactive Ingredients: Carnauba Wax, Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, Pregelatinized Starch, Sodium Starch Glycolate, Stearic Acid, Titanium Dioxide. Aralen - Clinical Pharmacology, chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55 of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times flagyl 500 mg sanofi the plasma concentration may be found in the liver, spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma. Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylchloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts. Slightly more than half of the urinary drug products can be accounted for as unchanged chloroquine. Microbiology, mechanism of Action, chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo. Chloroquine is active against the erythrocytic forms of Plasmodium vivax. Plasmodium malariae, and susceptible strains of Plasmodium falciparum (but not the gametocytes. It is not effective against exoerythrocytic forms of the parasite. In vitro studies with trophozoites of Entamoeba histolytica have demonstrated that chloroquine also possesses amebicidal activity comparable to that of emetine. Drug Resistance, resistance of Plasmodium falciparum to chloroquine is widespread and cases of Plasmodium vivax resistance have been reported. Indications and Usage for Aralen, aralen is indicated for the suppressive treatment and for acute attacks of malaria due. Ovale, and susceptible strains. The drug is also indicated for the treatment of extraintestinal amebiasis. Aralen does not prevent relapses in patients with vivax or malariae malaria because it is not effective against exoerythrocytic forms of the parasite, nor will it prevent vivax or malariae infection when administered as a prophylactic. It is highly effective as a suppressive agent in patients with vivax or malariae malaria, in terminating acute attacks, and significantly lengthening the interval between treatment and relapse. In patients with falciparum malaria it abolishes the acute attack and effects complete cure of the infection, unless due to a resistant strain. Use of this drug is contraindicated in the presence of retinal or visual field changes either attributable to 4-aminoquinoline compounds or to any other etiology, and in patients with known hypersensitivity to 4-aminoquinoline compounds. However, in the treatment of acute attacks of malaria caused by susceptible strains of plasmodia, the physician may elect to use this drug after carefully flagyl 500 mg sanofi weighing the possible benefits and risks to the patient. Warnings, it has been found that certain strains. Falciparum have become resistant to 4-aminoquinoline compounds (including chloroquine and hydroxychloroquine).

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