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In patients with falciparum malaria it abolishes the acute attack and effects complete cure of the infection, unless due to a resistant strain. Use of this drug is contraindicated in the presence of retinal or visual field changes either attributable to 4-aminoquinoline compounds or to any other etiology, and in patients with known hypersensitivity to 4-aminoquinoline compounds. However, in the treatment of acute attacks of malaria caused by susceptible strains of plasmodia, the physician may elect to use this drug after carefully flagyl 500 mg sanofi weighing the possible benefits and risks to the patient. Warnings, it has been found that certain strains. Falciparum have become resistant to 4-aminoquinoline compounds (including chloroquine and hydroxychloroquine).